Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi.

@article{Sawada2002LocalizationAR,
  title={Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi.},
  author={Hitoshi Sawada and Youko Takahashi and Junko Fujino and Sandra Y. Flores and Hideyoshi Yokosawa},
  journal={Molecular reproduction and development},
  year={2002},
  volume={62 2},
  pages={271-6}
}
We previously reported that sperm proteasome is responsible for degradation of the ubiquitinated vitelline-coat during fertilization in the ascidian Halocynthia roretzi. Here, we report the roles in fertilization and localization in the sperm cell surface of H. roretzi sperm proteasome. An anti-proteasome antibody, as well as the proteasome inhibitors MG115 and MG132, inhibited the fertilization, indicating that the sperm proteasome functions extracellularly in ascidian fertilization. In order… CONTINUE READING
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