Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function

Abstract

Ribosomal S6 kinase 1 (RSK1) belongs to a family of proteins with two kinase domains. Following activation in the cytoplasm by extracellular signal-regulated kinases (ERK1/2), it mediates the cell-proliferative, cell-growth, and survival-promoting actions of a number of growth factors and other agonists. These diverse biological actions of RSK1 involve… (More)
DOI: 10.1091/mbc.E11-07-0658

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