Localization and regulation of cytosolic phospholipase A(2).

  title={Localization and regulation of cytosolic phospholipase A(2).},
  author={Tetsuya Hirabayashi and Takako Shimizu},
  journal={Biochimica et biophysica acta},
  volume={1488 1-2},
Liberation of arachidonic acid by cytosolic phospholipase A(2) (cPLA(2)) upon cell activation is often the initial and rate-limiting step in leukotriene and prostaglandin biosynthesis. This review discusses the essential features of cPLA(2) isoforms and addresses intriguing insights into the catalytic and regulatory mechanisms. Gene expression, posttranslational modification and subcellular localization can regulate these isoforms. Translocation of cPLA(2)alpha from the cytosol to the… CONTINUE READING

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