Localization and regulation of SR-BI in membrane rafts of HepG2 cells.

  title={Localization and regulation of SR-BI in membrane rafts of HepG2 cells.},
  author={David Rhainds and Philippe Bourgeois and Genevi{\`e}ve Bourret and Karine Huard and Louise Falstrault and Louise Brissette},
  journal={Journal of cell science},
  volume={117 Pt 15},
The scavenger receptor class B, type I (SR-BI) mediates cholesteryl esters (CE) selective uptake from low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. In a number of tissues expressing caveolin, SR-BI is localized in caveolae. We show using detergent-free sucrose gradients that SR-BI is found in membrane rafts devoid of caveolin-1 in the human hepatoma HepG2 cell. Perturbation of the structure of HepG2 cell membrane rafts with cholesterol oxidase or sphingomyelinase… CONTINUE READING


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