Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X.

@article{Wagner1996LocalizationAP,
  title={Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X.},
  author={Belinda J. Wagner and Liangqi Long and P Nagesh Rao and Mark J. Pettenati and Gary Brewer},
  journal={Genomics},
  year={1996},
  volume={34 2},
  pages={219-22}
}
Messenger RNAs encoding many oncoproteins and cytokines are relatively unstable. Their instability, which ensures appropriate levels and timing of expression, is controlled in part by proteins that bind to A+U-rich instability elements (AREs) present in the 3'-untranslated regions of the mRNAs. cDNAs encoding the AUF1 family of ARE-binding proteins were cloned from human and murine cDNA libraries. In the present study monochromosomal somatic cell hybrids were used to localize two AUF1 loci to… CONTINUE READING

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