Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors.

@article{Zallocchi2009LocalizationAE,
  title={Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors.},
  author={Marisa Zallocchi and Daniel T. Meehan and Duane C. Delimont and Charles Askew and Suneetha Garige and Michael Anne Gratton and Christie A Rothermund-Franklin and Dominic Cosgrove},
  journal={Hearing research},
  year={2009},
  volume={255 1-2},
  pages={109-20}
}
The Usher syndrome 3A (CLRN1) gene encodes clarin-1, which is a member of the tetraspanin family of transmembrane proteins. Although identified more than 6 years ago, little is known about its localization or function in the eye and ear. We developed a polyclonal antibody that react with all clarin-1 isoforms and used it to characterize protein expression in cochlea and retina. In the cochlea, we observe clarin-1expression in the stereocilia of P0 mice, and in synaptic terminals present at the… CONTINUE READING
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