Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage

@article{Liu1999LocalizationAD,
  title={Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage},
  author={Yilun Liu and Ming-Jie Li and Eva Y-H.P. Lee and Nancy Maizels},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={975-978}
}
The importance of RAD52 in establishment and maintenance of genomic structure has been established by genetic experiments in the yeast Saccharomyces cerevisiae, where mutation of RAD52 has been shown to diminish DNA repair and recombination of a variety of markers, including the rDNA [1] [2] [3]. Biochemical analysis has shown that yeast and mammalian Rad52 proteins have some identical functions in vitro [4] [5] [6], but targeted deletion of Rad52 in vertebrates has little effect on repair and… CONTINUE READING

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Stasizk A, West SC: Binding of doublestrand breaks in DNA by human Rad52 protein

E van Dyck, AZ Stasiak
Nature • 1999
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