Localization and distribution of NOS1 in murine airways.

  title={Localization and distribution of NOS1 in murine airways.},
  author={Jichuan Shan and Paolo Carbonara and Nolan Karp and Meri C. Tulic and Qutayba A Hamid and David H. Eidelman},
  journal={Nitric oxide : biology and chemistry},
  volume={17 1},
Nitric oxide synthase 1 (NOS1) is a major determinant of bronchial responsiveness in mice and has been proposed as an asthma gene in man. Nevertheless, how nitric oxide production by NOS1 contributes to airway responsiveness remains unclear. Although NOS1 is usually closely associated with nerves, it has also been found in a variety of other cell types, particularly epithelium. We sought to better understand the role of NOS1 by determining its major site of expression in murine airways. Using… CONTINUE READING