Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development.

@article{Marr2007LocalizationAD,
  title={Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development.},
  author={Shauna H Marr and Heidi Morales and Andrea Bottaro and Michelle T Cooper and Martin Flajnik and Jacques Robert},
  journal={Journal of immunology},
  year={2007},
  volume={179 10},
  pages={
          6783-9
        }
}
As in mammals, B cell maturation in the amphibian Xenopus involves somatic hypermutation (SHM) and class switch recombination to diversify the B cell receptor repertoire in response to Ag stimulation. Unlike mammals, however, the resulting increase in Ab affinity is poor in Xenopus, which is possibly related to the absence of germinal centers and a suboptimal selection mechanism of SHM. In mammals, both SHM and class switch recombination are mediated by the activation-induced cytidine deaminase… CONTINUE READING
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