Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.


BACKGROUND The interactions of hyaluronan (HA) with proteins are important in extracellular matrix integrity and leukocyte migration and are usually mediated by a domain termed a Link module. Although the tertiary structure of a Link module has been determined, the molecular basis of HA-protein interactions remains poorly understood. RESULTS Isothermal… (More)