Localization and characterization of nitric oxide synthase in the rat suprachiasmatic nucleus: evidence for a nitrergic plexus in the biological clock.

@article{Chen1997LocalizationAC,
  title={Localization and characterization of nitric oxide synthase in the rat suprachiasmatic nucleus: evidence for a nitrergic plexus in the biological clock.},
  author={Duan P. Chen and William J Hurst and Jian M. Ding and Lia E. Faiman and B Mayer and Martha L U Gillette},
  journal={Journal of neurochemistry},
  year={1997},
  volume={68 2},
  pages={
          855-61
        }
}
Behavioral and electrophysiological evidence indicates that the biological clock in the hypothalamic suprachiasmatic nuclei (SCN) can be reset at night through release of glutamate from the retinohypothalamic tract and subsequent activation of nitric oxide synthase (NOS). However, previous studies using NADPH-diaphorase staining or immunocytochemistry to localize NOS found either no or only a few positive cells in the SCN. By monitoring conversion of L-[3H]arginine to L-[3H]-citrulline, this… CONTINUE READING

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