Localization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum.

@article{Allen1991LocalizationAC,
  title={Localization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum.},
  author={Andrew M Allen and George Paxinos and Michelle Mckinley and Shiwei Chai and Frederick A. O. Mendelsohn},
  journal={The Journal of comparative neurology},
  year={1991},
  volume={312 2},
  pages={
          291-8
        }
}
Angiotensin II (Ang II) binding sites were localized in the thalamus, basal ganglia, midbrain, and pons of the human central nervous system by in vitro autoradiography, employing 125I-[Sar1, Ile8]angiotensin II as the radioligand. High-density binding occurs in the substantia nigra pars compacta, the interpeduncular nucleus and two of the raphe nuclei, the raphe magnus, and median raphe nucleus. Moderate densities occur in the caudate nucleus, putamen, bed nucleus of the stria terminalis… CONTINUE READING
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