Localization and capacity of the last step of mercapturic acid biosynthesis and the reabsorption and acetylation of cysteine S-conjugates in the rat kidney

@article{Heuner1991LocalizationAC,
  title={Localization and capacity of the last step of mercapturic acid biosynthesis and the reabsorption and acetylation of cysteine S-conjugates in the rat kidney},
  author={Almut Heuner and Wolfgang Dekant and Johann S. Schwegler and Stefan Silbernagl},
  journal={Pfl{\"u}gers Archiv},
  year={1991},
  volume={417},
  pages={523-527}
}
We investigated the capacity and the localization of N-acetylation of the mercapturic acid precursor S-benzyl-l-cysteine (BC), as well as the tubular reabsorption of this compound in the rat kidney in vivo et situ by renal clearance and continuous microinfusion and microperfusion experiments. In renal clearance experiments, 450 μmol BC was infused intravenously for 180 min. During the time of BC infusion and the following 180 min, the two kidneys excreted 400 μmol or 90% of the infused BC dose… CONTINUE READING

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