Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites.

@article{Dodge2004LocalizationAA,
  title={Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites.},
  author={Matthew Dodge and Ross Frederick Waller and Larry Ming Cheung Chow and Muhammad M. Zaman and Leanne M. Cotton and Malcolm J. McConville and Dyann F Wirth},
  journal={Molecular microbiology},
  year={2004},
  volume={51 6},
  pages={
          1563-75
        }
}
Upregulation of the multidrug resistance protein 1 (LeMDR1) in the protozoan parasite, Leishmania enriettii, confers resistance to hydrophobic drugs such as vinblastine, but increases the sensitivity of these parasites to the mitochondrial drug, rhodamine 123. In order to investigate the mechanism of action of LeMDR1, the subcellular localization of green fluorescent protein (GFP)-tagged versions of LeMDR1 and the fate of the traceable-fluorescent LeMDR1 substrate calcein AM were examined in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS