Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin
@article{Carlton1995LocalizationAA, title={Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin}, author={Susan M. Carlton and Gregory L. Hargett and Richard E. Coggeshall}, journal={Neuroscience Letters}, year={1995}, volume={197}, pages={25-28} }
355 Citations
Localization and activation of substance P receptors in unmyelinated axons of rat glabrous skin
- BiologyBrain Research
- 1996
Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery
- BiologyThe Journal of comparative neurology
- 1998
The presence of glutamate receptors on large‐diameter myelinated axons suggests that these mechanosensitive receptors, presumably transducing touch and pressure, may also respond to local glutamate and thus be chemosensitive.
Inflammation-induced changes in peripheral glutamate receptor populations
- BiologyBrain Research
- 1999
Evidence for the interaction of glutamate and NK1 receptors in the periphery
- BiologyBrain Research
- 1998
Metabotropic glutamate 1α receptors on peripheral primary afferent fibers: their role in nociception
- BiologyBrain Research
- 2001
Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin
- BiologyPain research and treatment
- 2012
The results reveal that the activation of iGluRs and group I mGluR in peripheral afferent nerves play an important role in mechanisms whereby capsaicin evokes/maintains nociceptive responses.
Glutamate Receptors and Nociception
- BiologyCNS drugs
- 2001
Inhibition of glutamate release, or of glutamate receptors, in the spinal cord or periphery attenuates both acute and chronic pain in animal models and similar benefits have been seen in studies involving humans (both patients and volunteers); however, results have been inconsistent.
The glutamate synapse: a target in the pharmacological management of hyperalgesic pain states.
- BiologyProgress in brain research
- 1998
Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats.
- Biology, MedicineGastroenterology
- 2001
Peripheral NMDA receptors are important in normal visceral pain transmission, and may provide a novel mechanism for development of peripheral sensitization and visceral hyperalgesia.
Activation of Excitatory Amino Acid Receptors in Bovine Dental Pulp Evokes the Release of iCGRP
- BiologyJournal of dental research
- 1999
The results suggest that the activation of AMPA and kainate receptors in dental pulp may contribute to peripheral release of vasoactive neuropeptides which mediate a neurogenic component of inflammation.
References
SHOWING 1-10 OF 17 REFERENCES
Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain
- BiologyThe Journal of comparative neurology
- 1992
Staining was most prominent in forebrain structures such as the olfactory bulb and tubercle, septal nuclei, amygdaloid complex, hippocampus, induseum griseum, habenula, and interpeduncular nucleus, and in the cerebellum, with limited evidence of stained presynaptic terminals, excepting Bergmann glia.
Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1994
Data indicate that an NMDA autoreceptor is located in terminals ofPrimary afferent fibers, where it could facilitate the transmission of inputs to the spinal cord by increasing the release of neurotransmitter from the primary afferent terminal.
Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception.
- BiologyBrain research. Molecular brain research
- 1993
Activation of nociceptive reflexes by peripheral kainate receptors.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 1993
The existence of functional KA receptors on nociceptive afferents suggests that peripherally released glutamate or other excitatory amino acids could be involved in nOCiception or neurogenic inflammation.
The primary afferent depolarizing action of kainate in the rat
- BiologyBritish journal of pharmacology
- 1986
It is suggested that certain primary afferent C‐fibres possess kainate receptors which may be activated physiologically by L‐glutamate released at their central terminations.
Glutamate induces a depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptors
- BiologyNeuroscience Letters
- 1988
Organization of calcitonin gene‐related peptide‐immunoreactive terminals in the primate dorsal horn
- BiologyThe Journal of comparative neurology
- 1988
Of particular interest is the observation that CGRP‐immunoreactive terminals can be found presynaptic to other terminals which sometimes resemble central primary afferent endings, and the findings suggest thatPrimary afferent terminals interact synaptically with other primaryAfferent terminals.
Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1994
The data indicate that many neurons in each subfield of the hippocampus contain NMDAR-1 protein, although the intensity and distribution of immunoreactivity varied across regions, strata, and cellular compartments.
Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5/6/7
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
- 1993
Data indicate a high degree of selectivity in the distribution of kainate receptors composed of GluR5/6/7 subunits, and suggest that functional specificity and diversity in the ubiquitous excitatory amino acid-utilizing axonal systems in neocortex are achieved in part by the differential association of particular glutamate receptor subunits with specific cortical circuits.