Localization and abundance of fodrin during keratinocyte differentiation


Dear Editor: Fodrin (non-erythroid spectrin) is a member of the spectrin family of proteins usually found at the cytoplasmic side of the plasma membrane of many cell types. Functions that have been attributed to fodrin in non-erythroid cells include exocytosis of secretory granules from chromaffin cells, organization and regulation of receptor domains on plasma membranes, and establishment and maintenance of epithelial cell polarity (for review see 4,13). In vitro studies using cultured epithelial cells showed that with epithelial cell differentiation, fodrin distribution in the cells changes from diffuse cytoplasmic in the undifferentiated, to membranous in the differentiated cells (16,17,25,26). In proliferating epithelial cells in the colonic crypt in vivo, unlike proliferating epithelial cells in vitro, fodrin is membrane-associated, and it remains membrane-associated and increases in abundance with maturation of the epithelial cells as they reach the surface (26). In the mouse skin, the epidermis is usually two-layers thick. When the resting hair follicles (telogen) are stimulated to enter the proliferative phase (anagen), the epidermis also proliferates and increases in thickness. Differentiation of the mouse epidermal keratinocytes (MEK) takes place with migration toward the surface. Growth of the epidermis and hair follicles can be easily induced by hair plucking (1,2,18). Keratinocyte differentiation in vitro can be induced using a popular method known as the calcium switch model

DOI: 10.1007/BF02631393

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@article{Younes1994LocalizationAA, title={Localization and abundance of fodrin during keratinocyte differentiation}, author={Mamoun Younes and Ralf Paus and Kurt S. Stenn and Irwin M. Braverman and Agnes Keh-Yen}, journal={In Vitro Cellular & Developmental Biology - Animal}, year={1994}, volume={30}, pages={69-74} }