Localization and Phosphorylation of Abl-Interactor Proteins, Abi-1 and Abi-2, in the Developing Nervous System

@article{Courtney2000LocalizationAP,
  title={Localization and Phosphorylation of Abl-Interactor Proteins, Abi-1 and Abi-2, in the Developing Nervous System},
  author={Kevin D. Courtney and Matthew Grove and Hendrika M Vandongen and Antonius M. J. VanDongen and Anthony-Samuel LaMantia and Ann Marie Pendergast},
  journal={Molecular and Cellular Neuroscience},
  year={2000},
  volume={16},
  pages={244-257}
}
Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation. We asked if the expression, phosphorylation, and cellular localization of Abi-1 and Abi-2 supports a role for these proteins in Abl signaling in the developing and adult mouse nervous system. In mid- to late-gestation embryos, abi-2 message is elevated in the central and peripheral nervous systems (CNS and… 
The Involvement of Abl and PTP61F in the Regulation of Abi Protein Localization and Stability and Lamella Formation in Drosophila S2 Cells*
TLDR
This study found PTP61F, a Drosophila homolog of mammalian PTP1B, can reverse the Abl phosphorylation of Abi and colocalizes with Abi in Droseophila S2 cells, suggesting that the reciprocal regulation ofAbi phosphorylated by Abl and PTP 61F may regulate the localization and stability of Abu and may regulating the formation of lamella.
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TLDR
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TLDR
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TLDR
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TLDR
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Homo- and hetero-oligomerization of the c-Abl kinase and Abelson-interactor-1.
TLDR
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Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis
TLDR
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TLDR
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TLDR
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