Localised micro-mechanical stiffening in the ageing aorta

  title={Localised micro-mechanical stiffening in the ageing aorta},
  author={Helen K. Graham and Riaz Akhtar and Constantinos Kridiotis and Brian Derby and Tribikram Kundu and Andrew W. Trafford and Michael J Sherratt},
  booktitle={Mechanisms of Ageing and Development},
Age-related loss of tissue elasticity is a common cause of human morbidity and arteriosclerosis (vascular stiffening) is associated with the development of both fatal strokes and heart failure. However, in the absence of appropriate micro-mechanical testing methodologies, multiple structural remodelling events have been proposed as the cause of arteriosclerosis. Therefore, using a model of ageing in female sheep aorta (young: <18 months, old: >8 years) we: (i) quantified age-related macro… CONTINUE READING
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Physical Properties of Tissue

  • F. A. Duck
  • 1990
Highly Influential
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