Localisation of the GABAC receptors at the axon terminal of the rod bipolar cells of the mouse retina

@article{Vaquero1999LocalisationOT,
  title={Localisation of the GABAC receptors at the axon terminal of the rod bipolar cells of the mouse retina},
  author={Cecilia F. Vaquero and Pedro de la Villa},
  journal={Neuroscience Research},
  year={1999},
  volume={35},
  pages={1-7}
}
Voltage-activated Ca2+ channels and ionotropic GABA receptors localized at axon terminals of mammalian retinal bipolar cells
  • Z. Pan
  • Biology
    Visual Neuroscience
  • 2001
TLDR
Results of this study support the notion that both types of ionotropic GABA receptors regulate synaptic transmission in mammalian rod bipolar cells and demonstrate the localization of LVA Ca2+ channels at the axon terminal of mammalian retinal bipolar cells, suggesting that LVA calcium channels may play a role in bipolar cell transmitter release.
Electrophysiological evidence of GABAA and GABAC receptors on zebrafish retinal bipolar cells
TLDR
Modelling of inhibitory circuitry models for ON and OFF pathways in zebrafish retina found axon terminals contain bicuculline-sensitive GABAA receptors and both picrotoxin-sensitive and insensitive GABAC receptors, and dendritic processes express zinc- and picroToxin- sensitive GABac receptors.
Transporter-mediated GABA responses in horizontal and bipolar cells of zebrafish retina
TLDR
It is suggested Na+ drives GABA into cells, depolarizing the plasma membrane and triggering Na+, K+-dependent ATPase, which generates AHP, which may provide an outer plexiform layer GABA sensor mechanism.
Temporal modulation of scotopic visual signals by A17 amacrine cells in mammalian retina in vivo.
TLDR
The A17 feedback, activated by light stimulation and mediated mainly by the GABA(c) receptors, makes the scotopic b-wave more transient by accelerating preferentially its decay, which can be modulated by GABA(a) receptor-mediated inhibition and by light intensity.
Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses
TLDR
This review summarized current knowledge about the types of the GABAergic neurons and ionotropic GABA receptors in the retina as well as the effects of GABA and specific GABAA and GABAC receptor antagonists on the activity of the ON and OFF bipolar cells in both nonmammalian and mammalian retina.
Patch-clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin-slice preparation of the mammalian retina.
TLDR
It is demonstrated that axon terminals of rod bipolar cells are directly accessible to whole cell and outside-out patch recordings, extending the usefulness of this preparation for detailed studies of pre- and postsynaptic mechanisms of synaptic transmission in the CNS.
Dynamics of GABA&rgr;2 receptors in retinal bipolar neurons and cerebellar astrocytes
TLDR
In bipolar neurons, time-lapse laser confocal microscopy revealed that the fluorescence emitted by GABA&rgr;2–green fluorescent protein accumulates first, in clusters, in the soma and is then distributed along the axon in at least two populations: one that remains relatively immobile and a second population of smaller clusters that moved constantly to and from theAxon end.
GABA(C) receptors in retina and brain.
TLDR
This chapter focuses on the distribution of GABA(C) receptors and their possible function in various brain areas.
Cholecystokinin-like immunoreactive amacrine cells in the rat retina
TLDR
The goals of this study were to characterize the cells containing CCK, identify cell types that interact with CCK cells, and investigate the effects of CCK on rod bipolar cells.
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Different contributions of GABAA and GABAC receptors to rod and cone bipolar cells in a rat retinal slice preparation.
TLDR
A functional role for the modulation of GABAC receptors by the metabotropic glutamate receptors mGluR1/5 is suggested, supporting the hypothesis of distinct functional roles for the different types of cone bipolar cells.
A novel GABA receptor on bipolar cell terminals in the tiger salamander retina
TLDR
GA receptors on bipolar terminals appear to be pharmacologically different from the GABA receptors found on ganglion cell dendrites, which is similar to the pharmacology reported for the rho 1 GABA receptor subunit that was isolated from retina and expressed in Xenopus oocytes.
GABA- and glycine-activated currents in the rod bipolar cell of the rabbit retina.
TLDR
The data strongly suggest that the GABA-activated currents in rabbit rod bipolar cells are mediated by the GABAA receptor, and argue against the existence of a GABAC-type channel in the rod bipolar cell of the rabbit.
Voltage- and transmitter-gated currents in isolated rod bipolar cells of rat retina.
TLDR
Pressure application of the drugs from fine microcapillaries to various parts of the isolated cells suggests a high GABA sensitivity at the axonal endings compared with either the somatic or dendritic region.
GABA-gated Cl− Channels in the rat retina
Membrane currents evoked by ionotropic glutamate receptor agonists in rod bipolar cells in the rat retinal slice preparation.
TLDR
The results indicate that ionotropic glutamate receptors are not involved in mediating synaptic input from photoreceptors to rod bipolar cells and that an unconventional mechanism of GABA release from amacrine cells might operate in the inner plexiform layer.
Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells
TLDR
GABA gates bicuculline- and baclofen-insensitive GABA receptors in rod bipolar cells of the rat retina were activated selectively by the GABA analogue cis-4-aminocrotonic acid (CACA) and may be similar to those receptors termed GABAC receptors.
Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals
  • Z. Pan, S. Lipton
  • Biology, Chemistry
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
A functional role for multiple GABA receptors in regulating synaptic transmission at bipolar cell terminals is implied and is appropriate to refer to this receptor as a picrotoxin-insensitive GABAc receptor.
Different combinations of GABAA and GABAC receptors confer distinct temporal properties to retinal synaptic responses.
TLDR
The data show that the prolonged synaptic responses in bipolar cells were mediated predominantly by GABAC receptors, whereas transient synaptic responding in ganglion cells were soluble in GABAA receptors.
Presynaptic inhibition by GABA is mediated via two distinct GABA receptors with novel pharmacology
TLDR
It is argued on functional grounds that the two GABA receptors coupled to Cl channels and to Ca channels are best regarded as members of the GABAA and GABAB families, respectively.
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