Localisation of somatostatin and somatostatin receptors in benign and malignant ovarian tumours

@article{Hall2002LocalisationOS,
  title={Localisation of somatostatin and somatostatin receptors in benign and malignant ovarian tumours},
  author={Glen H Hall and L W Turnbull and Ian Richmond and Lone Helboe and Stephen L Atkin},
  journal={British Journal of Cancer},
  year={2002},
  volume={87},
  pages={86 - 90}
}
Somatostatin has been identified as having anti-proliferative, anti-angiogenic and pro-apoptotic actions in many tumour systems, and these effects are mediated through a family of five transmembrane G-protein coupled SRIF receptors. Ovarian cancer is the commonest gynaecological malignancy in the UK and maintenance therapy is urgently required. Native somatostatin expression and its receptors sst1,2,3 and 5 were studied with immunohistochemistry in 63 malignant and 35 benign ovarian tumours of… CONTINUE READING
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