Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

@article{Bradford2014LocalisationOC,
  title={Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis},
  author={Claire M. Bradford and In{\^e}s I. Ramos and Alison K. Cross and Gail Haddock and Stephen McQuaid and Anthony P. Nicholas and M. Nicola Woodroofe},
  journal={Journal of Neuroimmunology},
  year={2014},
  volume={273},
  pages={85-95}
}
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity. Here we investigated the expression of citrullinated proteins in active MS lesions, MS normal appearing white matter and… CONTINUE READING

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