Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart.

@article{Facer2011LocalisationOS,
  title={Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart.},
  author={Paul Facer and Prakash P. Punjabi and Andleeb Abrari and Riyaz A Kaba and Nicholas John Severs and John Chambers and Jaspal Singh Kooner and Praveen Anand},
  journal={International heart journal},
  year={2011},
  volume={52 3},
  pages={
          146-52
        }
}
We have shown that the gene SCN10A encoding the sodium channel Na(v)1.8 is a susceptibility factor for heart block and serious ventricular arrhythmia. Since Na(v)1.8 is known to be present in nerve fibres that mediate pain, it may be related to both cardiac pain and dysrhythmia. The localisation of Na(v)1.8 and other key nociceptive ion channels, including Na(v)1.7, Na(v)1.9, capsaicin receptor TRPV1, and purinergic receptor P2X(3), have not been reported in human heart. The aim of this study… CONTINUE READING

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