Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans

@article{Bergman2011LocalisationAC,
  title={Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans},
  author={Bryan C. Bergman and Devon M. Hunerdosse and Anna A. Kerege and Mary C Playdon and Leigh Perreault},
  journal={Diabetologia},
  year={2011},
  volume={55},
  pages={1140-1150}
}
We sought to evaluate if the cellular localisation and molecular species of diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. Healthy sedentary obese controls (Ob; n = 6; mean±SEM age 39.5 ± 2.3 years; mean±SEM BMI 33.3 ± 1.4 kg/m2), individuals with type 2 diabetes (T2D; n = 6; age 44 ± 1.8 years; BMI 30.1 ± 2.3 kg/m2), and lean endurance-trained athletes (Ath; n = 10; age 35.4 ± 3.1 years; BMI 23.3 ± 0.8 kg/m2) were studied. Insulin sensitivity was determined… CONTINUE READING

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Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects

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2 Excerpts

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