Local versus systemically mediated effects of estrogen on normal mammary epithelial cell deoxyribonucleic acid synthesis.

@article{Haslam1988LocalVS,
  title={Local versus systemically mediated effects of estrogen on normal mammary epithelial cell deoxyribonucleic acid synthesis.},
  author={Sandra Z. Haslam},
  journal={Endocrinology},
  year={1988},
  volume={122 3},
  pages={860-7}
}
While it has been shown that estrogen promotes mammary gland growth in vivo, it has not been demonstrated if estrogen acts locally in the mammary gland to produce a mitogenic effect in the epithelial cells or if the mitogenic effect is mediated systemically. The purpose of this study was to distinguish between local vs. systemically mediated modes of estrogen action in normal mammary glands of both immature 5-week-old and sexually mature 10-week-old mice. Elvax 40P, noninflammatory, easily… CONTINUE READING