Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT3 receptor antagonist tropisetron

@article{Mller2004LocalTO,
  title={Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT3 receptor antagonist tropisetron},
  author={W. M{\"u}ller and Thomas Stratz},
  journal={Scandinavian Journal of Rheumatology},
  year={2004},
  volume={33},
  pages={44 - 48}
}
  • W. Müller, T. Stratz
  • Published 1 June 2004
  • Medicine, Biology
  • Scandinavian Journal of Rheumatology
The use of local tropisetron injections improved the treatment of tendinopathies considerably, with the effect being comparable to the topical application of local anaesthetics combined with depot corticosteroids. On the other hand, local injection of prilocaine alone exerted a shorter and weaker effect on the condition. Objectives: After it had been proven that systemic application of the 5‐HT3 receptor antagonist tropisetron exerts an analgesic effect on musculoskeletal pain in fibromyalgia… 
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References

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Local treatment of tendinopathies: a comparison between tropisetron and depot corticosteroids combined with local anesthetics
TLDR
Local injection of tropisetron seems to be as safe and as effective as the combination of corticosteroids and local anesthetics in the treatment of painful tendinopathies.
The use of 5-HT3 receptor antagonists in various rheumatic diseases - a clue to the mechanism of action of these agents in fibromyalgia?
  • T. Müller
  • Medicine
    Scandinavian journal of rheumatology. Supplement
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TLDR
The majority of patients with localized soft-tissue rheumatic diseases (periarthritis) demonstrated an obvious decrease in their pain following local infiltration of tropisetron, which might imply that 5-HT3 receptor antagonists could supplement or replace the local administration of corticosteroids.
The Use of the 5-HT3 Receptor Antagonist Tropisetron in Trigger Point Therapy: A Pilot Study
TLDR
Trigger point injection with the 5-HT3 receptor antagonist tropisetron reduces pain in myofascial pain syndromes and can be attributed to the substance's analgesic effect, and moreover, probably also to its anti-inflammatory action.
Treatment of tendopathies with tropisetron
Abstract. A comparison between a local anesthetic drug and the 5-hydroxytryptamine 3 (5-HT3) receptor antagonist tropisetron in treating tendopathies or periarthropathies revealed that tropisetron
Efficacy and tolerability of tropisetron in primary fibromyalgia - a highly selective and competitive 5-HT3 receptor antagonist
TLDR
The efficacy of short-term treatment with 5 mg tropisetron once daily in primary fibromyalgia was well tolerated and prolonged clinical benefits were seen, in keeping with the known safety profile for 5-HT3 receptor antagonists.
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In more than 40% of patients with fibromyalgia a marked influence on the pain in the skeletal system with a decrease of the tenderness at "tenderpoints" can be achieved by blocking the
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TLDR
It is concluded that activation of both peripheral and central 5-HT3 receptors is pronociceptive and that the contribution of peripheral 5- HT3 receptors involves a novel complement of primary afferent nociceptors.
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