Local translation in neuronal processes--in vivo tests of a "heretical hypothesis".

  title={Local translation in neuronal processes--in vivo tests of a "heretical hypothesis".},
  author={Rotem Ben-Tov Perry and Mike Fainzilber},
  journal={Developmental neurobiology},
  volume={74 3},
Intracellular trafficking and localization of mRNA is a fundamental feature of living cells, suggesting that localized mRNA translation should enable subcellular regulation of the proteome. Such localized regulation may be of particular importance in highly polarized cells such as neurons, where the requirement for a specific protein can be at a site far distant from the nucleus. Although dendritic and synaptic protein syntheses are well-established phenomena, the apparent paucity of ribosomes… CONTINUE READING

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