Local toxicity from local anesthetic polymeric microparticles.


BACKGROUND Local tissue injury from sustained-release formulations for local anesthetics can be severe. There is considerable variability in reporting of that injury. We investigated the influence of the intrinsic myotoxicity of the encapsulated local anesthetic (lidocaine, low; bupivacaine, high) on tissue reaction in rats. METHODS Cytotoxicity from a… (More)
DOI: 10.1213/ANE.0b013e31828174a7


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