Local thyroid renin-angiotensin system in experimental breast cancer.

  title={Local thyroid renin-angiotensin system in experimental breast cancer.},
  author={M. Carrera-Gonz{\'a}lez and M. J. Ram{\'i}rez-Exp{\'o}sito and M. D. Mayas and M. J. Garc{\'i}a and J. Mart{\'i}nez-Martos},
  journal={Life sciences},
  volume={93 25-26},
UNLABELLED An association between breast cancer and thyroid dysfunction exists although the underlying mechanisms remain to be elucidated. Numerous studies have characterized the role of thyroid hormones in controlling the synthesis and secretion of renin-angiotensin system (RAS) components, but little information is available on the putative role of the local RAS on thyroid function. AIMS Here we analyze several soluble and membrane-bound RAS-regulating aminopeptidase activities in thyroid… Expand
Synchronous primary cancers of the thyroid and breast: A case report and review of the literature
The aim of the current report was to improve the understanding of synchronous primary cancers of the thyroid and breast by presenting a review of the associated literature regarding breast and thyroid cancer and to provide a reference for the cancer database. Expand


Hypothalamus–pituitary–thyroid axis disruption in rats with breast cancer is related to an altered endogenous oxytocin/insulin-regulated aminopeptidase (IRAP) system
It is proposed that breast cancer increases OXT pituitary release by decreasing its hypothalamic catabolism through IRAP activity, probably due to the alteration of the estrogenic endocrine status, supporting the association between breast cancer and thyroid function disruption. Expand
Renin angiotensin system-regulating aminopeptidase activities in serum of pre- and postmenopausal women with breast cancer.
A slow metabolism of angiotensin II (Ang II) to angiotENSin III (Ang III) in premenopausal women and a rapid metabolism of Ang III to ang Elliotensin IV (Ang IV) inPre- and post menopausal women with breast cancer are suggested. Expand
Tissue-specific modulation of angiotensin-converting enzyme (ACE) in hyperthyroidism
Both doses promoted increased renal ACE activity and expression but surprisingly ACE was diminished in the heart in both hyperthyroid groups, mediated by a tissue-specific transcription mechanism. Expand
Hormonal status modifies renin-angiotensin system-regulating aminopeptidases and vasopressin-degrading activity in the hypothalamus-pituitary-adrenal axis of male mice.
The present data suggest that in male mice, testosterone influences the RAS- and vasopressin-degrading activities at all levels of the HPA axis. Expand
Renin‐Angiotensin System in Thyroid Dysfunction in Rats
Thyroid dysfunction causes significant changes in the RAS and in AT receptor density, especially of the AT2 subtype, and selective AT2-receptor antagonists may prove therapeutically useful in treatment of cardiovascular disease in thyroid dysfunction. Expand
Effect of thyroid hormones on angiotensinogen production in the rat in vivo and in vitro.
The influence of thyroid hormones on angiotensinogen production was studied in vitro and in vivo and addition of various concentrations of T4 or T3 to monolayer cultures of adult rat hepatocytes significantly enhanced APR. Expand
Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer.
It is proposed that the reduction in risk associated with hyperthyroidism or increased levels of thyroid hormones, or iodine, may derive from the pro-oxidant properties of these compounds, i.e., from its ability to generate oxidative stress-induced apoptosis. Expand
Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system.
Recent advances in understanding the relationship between endocrine and paracrine (tissue) RAS using transgenic models are discussed in a minireview of renin-angiotensin system. Expand
Characterization of angiotensin II receptors (binding and mRNA) in the rat thyroid gland.
The existence of a moderate density of specific angiotensin II (Ang II) binding sites in plasma membrane preparations from rat thyroid gland supports a reciprocal regulation of thyroid function by the RAS. Expand
Hormonal control of angiotensinogen production.
It is concluded that hepatic angiotensinogen biosynthesis is under hormonal control, which may in part explain the pathogenesis of hypertension associated with certain disease states. Expand