Local stimulation of prostaglandin production by corticotropin-releasing hormone in human fetal membranes and placenta.

@article{Jones1989LocalSO,
  title={Local stimulation of prostaglandin production by corticotropin-releasing hormone in human fetal membranes and placenta.},
  author={Sidney A Jones and John R. G. Challis},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={159 1},
  pages={192-9}
}
Corticotropin-releasing hormone is produced by the human placenta and fetal membranes, but its physiological significance is not established. We examined the possibility that CRH might affect prostaglandin output by these intra-uterine tissues. Primary cultures of amnion, chorion, decidua and placenta were established from tissue obtained from women at term elective cesarean section were maintained in the presence of increasing concentrations of synthetic hCRH. PG output at 48h was measured by… CONTINUE READING
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