Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

@article{Kohli2010LocalST,
  title={Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.},
  author={Rahul M Kohli and Robert W Maul and Amy F Guminski and Rhonda L. McClure and Kiran S. Gajula and Huseyin Saribasak and Moira A. McMahon and Robert F. Siliciano and Patricia J Gearhart and James T Stivers},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 52},
  pages={40956-64}
}
Nucleic acid cytidine deaminases of the activation-induced deaminase (AID)/APOBEC family are critical players in active and innate immune responses, playing roles as target-directed, purposeful mutators. AID specifically deaminates the host immunoglobulin (Ig) locus to evolve antibody specificity, whereas its close relative, APOBEC3G (A3G), lethally mutates the genomes of retroviral pathogens such as HIV. Understanding the basis for the target-specific action of these enzymes is essential, as… CONTINUE READING
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Functional Impact of AID/APOBEC Sequence

  • K. M. Chen, E. Harjes, +4 authors Harris
  • Targeting DECEMBER
  • 2010

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