Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity

Abstract

Promising anti-tumor responses have been observed in the clinic using monoclonal antibodies (mAbs) that block immune checkpoints. One concern with these therapeutic agents remains the potential induction of immune breakthrough events (IBEs) resulting from the disruption of T cell homeostasis or the breaking of tolerance to self antigens. As an approach to… (More)
DOI: 10.1007/s00262-008-0451-3

Topics

4 Figures and Tables

Cite this paper

@article{Simmons2008LocalSO, title={Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity}, author={Andrew D. Simmons and Marina Moskalenko and Jennifer Creson and Jianmin Fang and Saili Yi and Melinda Vanroey and James Patrick Allison and Karin Jooss}, journal={Cancer Immunology, Immunotherapy}, year={2008}, volume={57}, pages={1263-1270} }