Local secondary structure content predicts folding rates for simple, two-state proteins.

@article{Gong2003LocalSS,
  title={Local secondary structure content predicts folding rates for simple, two-state proteins.},
  author={Haipeng Gong and Daniel G Isom and Rajgopal Srinivasan and George D. Rose},
  journal={Journal of molecular biology},
  year={2003},
  volume={327 5},
  pages={1149-54}
}
Many single-domain proteins exhibit two-state folding kinetics, with folding rates that span more than six orders of magnitude. A quantity of much recent interest for such proteins is their contact order, the average separation in sequence between contacting residue pairs. Numerous studies have reached the surprising conclusion that contact order is well-correlated with the logarithm of the folding rate for these small, well-characterized molecules. Here, we investigate the physico-chemical… CONTINUE READING

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