Local-scale repetitiveness in amino acid use in eukaryote protein sequences: a genomic factor in protein evolution.

@article{Nishizawa1999LocalscaleRI,
  title={Local-scale repetitiveness in amino acid use in eukaryote protein sequences: a genomic factor in protein evolution.},
  author={Masafumi Nishizawa and Keito Nishizawa},
  journal={Proteins},
  year={1999},
  volume={37 2},
  pages={
          284-92
        }
}
We showed previously that the use of arginine versus lysine residues in eukaryote proteins is correlated positively with local GC content of the genome within approximately 50 residues. Cumulative analyses show that the tendency for self-clustering (or repetitive use) generally is the case for all types of amino acids except for certain hydrophobic types. The degree to which each of the amino acids is used recurrently is weak for ancient proteins (or protein domains), those that are conserved… CONTINUE READING