Local regulation of human breast xenograft models.

  title={Local regulation of human breast xenograft models.},
  author={Jodie M Fleming and Tyler C. Miller and Matthew J. Meyer and E. Ginsburg and Barbara K. Vonderhaar},
  journal={Journal of cellular physiology},
  volume={224 3},
Breast cancer studies implant human cancer cells under the renal capsule, subcutaneously, or orthotopically and often use estrogen supplementation and immune suppressants (etoposide) in xenograft mouse models. However, cell behavior is significantly impacted by signals from the local microenvironment. Therefore, we investigated how the combinatorial effect of the location of injection and procedural differences affected xenograft characteristics. Patient-derived breast cancer cells were… CONTINUE READING


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