Local regulation of gonadotroph function by pituitary gonadotropin-releasing hormone.

@article{Krsmanovic2000LocalRO,
  title={Local regulation of gonadotroph function by pituitary gonadotropin-releasing hormone.},
  author={Lazar Z. Krsmanovic and Antonio J. Mart{\'i}nez-Fuentes and Krishan K Arora and Nadia Mores and Melanija Tomi{\'c} and Stanko S. Stojilkovic and Kevin J. Catt},
  journal={Endocrinology},
  year={2000},
  volume={141 3},
  pages={1187-95}
}
Cultured rat pituitary cells and immortalized pituitary gonadotrophs (alphaT3-1 cells) express specific messenger RNA transcripts for GnRH and exhibit positive immunostaining for the GnRH peptide. Each cell type released GnRH during both static culture and perifusion, albeit in lesser amounts than cultured hypothalamic cells and GT1-7 neurons. In perifused pituitary cells, exposure to a GnRH agonist stimulated the release of GnRH as well as LH. In contrast, treatment with a GnRH receptor… CONTINUE READING
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Developmental and physiological aspects of Ca21 signaling in agonist-stimulated pituitary gonadothrops

  • M Tomic, M Cesnjaj, KJ Catt, SS Stojilkovic
  • Endocrinology
  • 1994
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