Local recovery of Ca2+ release in rat ventricular myocytes.

@article{Sobie2005LocalRO,
  title={Local recovery of Ca2+ release in rat ventricular myocytes.},
  author={Eric A. Sobie and Long-Sheng Song and W. Jonathan Lederer},
  journal={The Journal of physiology},
  year={2005},
  volume={565 Pt 2},
  pages={
          441-7
        }
}
Excitation-contraction coupling in the heart depends on the positive feedback process of Ca2+-induced Ca2+ release (CICR). While CICR provides for robust triggering of Ca2+ sparks, the mechanisms underlying their termination remain unknown. At present, it is unclear how a cluster of Ca2+ release channels (ryanodine receptors or RyRs) can be made to turn off when their activity is sustained by the Ca2+ release itself. We use a novel experimental approach to investigate indirectly this issue by… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS, ESTIMATED 57% COVERAGE

73 Citations

051015'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 73 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…