Local protons and uncoupling of aerobic and artificial delta muH-driven ATP synthesis.

@article{Luvisetto1989LocalPA,
  title={Local protons and uncoupling of aerobic and artificial delta muH-driven ATP synthesis.},
  author={S Luvisetto and Giovanni Felice Azzone},
  journal={Biochemistry},
  year={1989},
  volume={28 3},
  pages={1109-16}
}
Gramicidin D causes inhibition of ATP synthesis either in the absence or in the presence of depression of delta muH, in low-salt and in high-salt media, respectively, at concentrations 2 orders of magnitude higher in the former with respect to the latter case. When the number of active redox pumps is reduced by increasing the antimycin concentration, the P/O ratio of respiring, gramicidin-treated mitochondria either is slightly increased in low-salt media or is first decreased and then constant… CONTINUE READING