Local protein instability predictive of helper T-cell epitopes.

  title={Local protein instability predictive of helper T-cell epitopes.},
  author={S. J. Landry},
  journal={Immunology today},
  volume={18 11},
Although selectivity at the levels of peptide binding to major histocompatibility complex (MHC) class II and recognition by T cells may partially account for immunodominance patterns, it is clear that differential antigen processing also exerts a strong effect. Here, Sam Landry correlates immunodominant epitopes with nearby structurally unstable segments, as identified by hydrogen-deuterium exchange nuclear magnetic resonance (NMR), and suggests that epitope presentation is directed by… CONTINUE READING

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