Local proliferation dominates lesional macrophage accumulation in atherosclerosis

@inproceedings{Robbins2013LocalPD,
  title={Local proliferation dominates lesional macrophage accumulation in atherosclerosis},
  author={Clinton S. Robbins and Ingo Hilgendorf and Georg F Weber and Igor M Theurl and Yoshiko Iwamoto and Jose-Luiz Figueiredo and Rostic Gorbatov and Galina K Sukhova and Louisa M. S. Gerhardt and David Ishii Smyth and Caleb C. J. Zavitz and Eric Akihiko Shikatani and Michael E Parsons and Nico Van Rooijen and Herbert Y. Lin and Mansoor Husain and Peter Libby and Matthias Nahrendorf and Ralph Weissleder and Filip K Swirski},
  booktitle={Nature Medicine},
  year={2013}
}
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall. The observation that circulating monocytes give rise to lesional macrophages has reinforced the concept that monocyte infiltration dictates macrophage buildup. Recent work has indicated, however, that macrophage accumulation does not depend on monocyte recruitment in some inflammatory contexts. We therefore revisited the mechanism underlying macrophage accumulation in… CONTINUE READING
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