Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.

@article{Peng2008LocalPA,
  title={Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.},
  author={Qi Peng and Ke Li and Katie J Anderson and Conrad A. Farrar and Bao Shi Lu and Richard A. G. Smith and Steven H Sacks and Wuding Zhou},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={2452-61}
}
Donor cell expression of C3 enhances the alloimmune response and is associated with the fate of transplantation. To clarify the mechanism for enhancement of the immune response, we have explored the role of C3a receptor (C3aR)-ligand interaction on murine bone marrow dendritic cells (DCs). We show that DCs either lacked receptor for C3a (a C3 cleavage product) or were treated with C3aR antagonist, elicited defective T-cell priming against alloantigen expressed on the DCs. This was associated… CONTINUE READING