Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

@inproceedings{Cai2013LocalPO,
  title={Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression},
  author={Xiang Cai and Angy J. Kallarackal and Mark D. Kvarta and Sasha Goluskin and Kaitlin Gaylor and Aileen M. Bailey and Hey-Kyoung Lee and Richard L. Huganir and Scott M. Thompson},
  booktitle={Nature Neuroscience},
  year={2013}
}
The causes of major depression remain unknown. Antidepressants elevate concentrations of monoamines, particularly serotonin, but it remains uncertain which downstream events are critical to their therapeutic effects. We found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic pathway with CA1 pyramidal cells via activation of serotonin receptors (5-HT1BRs), without affecting nearby Schaffer collateral synapses. This potentiation was expressed… CONTINUE READING