Local platelet activation causes vasoconstriction of large epicardial canine coronary arteries in vivo. Thromboxane A2 and serotonin are possible mediators.

@article{Golino1989LocalPA,
  title={Local platelet activation causes vasoconstriction of large epicardial canine coronary arteries in vivo. Thromboxane A2 and serotonin are possible mediators.},
  author={Paolo Golino and J. H. Ashton and Luis Maximilian Buja and Mark Rosolowsky and Anne L. Taylor and JANICE M. MCNATT and William Campbell and James T. Willerson},
  journal={Circulation},
  year={1989},
  volume={79 1},
  pages={154-66}
}
The goal of the present study was to demonstrate that intracoronary platelet deposition may trigger intense vasoconstriction of large epicardial coronary arteries in vivo and that this is largely mediated by thromboxane A2 and serotonin released by activated platelets. Cyclic flow variations (progressive declines in blood flow followed by sudden restorations of flow) due to recurrent intracoronary platelet activation and thrombus formation were induced by damaging the endothelium and placing a… CONTINUE READING
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Epinephrine reverses inhibition of cyclic reductions in flow in stenosed canine coronary arteries by serotonin 2 or thromboxane A 2 / prostaglandin H 2 receptor antagonists ( abstract )

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Intracoronary distribution of ` Inlabeled platelets in dogs with experimental coronary stenoses ( abstract )

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Protective effect of serotonin S 2 and thromboxane Az / prostaglandin H 2 antagonists in epinephrineinduced intermittent thrombosis in narrowed canine coronary arteries ( abstract )

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  • Circulation
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