Local paclitaxel induces late lumen enlargement in coronary arteries after balloon angioplasty

Abstract

This study investigated p aclitaxel-induced luminal changes following drug-coated balloon (DCB) angioplasty to treat coronary de novo lesions without additional stenting. DCB-mediated local drug delivery reduces late lumen loss in de novo coronary artery lesions. We performed a retrospective clinical assessment based on a pre-specified quantitative coronary angiography (QCA) protocol. QCA was performed for each centre to assess the primary endpoint late lumen changes, i.e. the difference between in-lesion minimal lumen diameter (MLD) at the routine angiographic follow-up as compared to post-procedural in-lesion MLDs. These MLD changes were compared to corresponding reference vessel diameter changes as an intra-patient control. We evaluated 58 consecutive native coronary artery lesions directly after DCB angioplasty and at a routine target follow-up angiography of 4 months by QCA. Target lesion MLD increased significantly within the 4.1 ± 2.1 month observation period (1.75 ± 0.55 vs. 1.91 ± 0.55 mm, p < 0.001, diameter stenosis 33.8 ± 12.3 vs. 26.9 ± 13.8 %, p < 0.001), while there were no changes in non-target reference vessel diameters (2.33 ± 0.60 vs. 2.34 ± 0.61 mm, p = ns). A total of 69 % of patients showed luminal enlargement whereas 29 % had minor luminal loss. Local application of paclitaxel by DCB angioplasty to native coronary arteries after pre-dilatation without major dissection and recoil leads to late lumen increase.

DOI: 10.1007/s00392-014-0775-2

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@article{Kleber2014LocalPI, title={Local paclitaxel induces late lumen enlargement in coronary arteries after balloon angioplasty}, author={Franz Xaver Kleber and Antonia Schulz and Matthias Waliszewski and Telse Hauschild and Michael B{\"{o}hm and Ulrich Andr{\'e}as Dietz and Bodo Cremers and Bruno Scheller and Yvonne Patricia Clever}, journal={Clinical Research in Cardiology}, year={2014}, volume={104}, pages={217-225} }