Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats.

@article{Ross2007LocalNO,
  title={Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats.},
  author={Renee M Ross and Glenn D Wadley and Michael S. G. Clark and Stephen Rattigan and Glenn Kevin McConell},
  journal={Diabetes},
  year={2007},
  volume={56 12},
  pages={2885-92}
}
OBJECTIVE We have previously shown in humans that local infusion of a nitric oxide synthase (NOS) inhibitor into the femoral artery attenuates the increase in leg glucose uptake during exercise without influencing total leg blood flow. However, rodent studies examining the effect of NOS inhibition on contraction-stimulated skeletal muscle glucose uptake have yielded contradictory results. This study examined the effect of local infusion of an NOS inhibitor on skeletal muscle glucose uptake (2… CONTINUE READING