Local nitric oxide release does not affect tachyphylaxis to angiotensin II in dorsal hand veins in man in the presence of prostaglandin synthesis inhibition.

@article{Haas2002LocalNO,
  title={Local nitric oxide release does not affect tachyphylaxis to angiotensin II in dorsal hand veins in man in the presence of prostaglandin synthesis inhibition.},
  author={Sanne L de Haas and Ian B. Wilkinson and Jason L. Boyd and David J. Webb},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={53 2},
  pages={193-5}
}
AIMS Local prostaglandin (PG) production contributes to tachyphylaxis to angiotensin II (ANGII) in veins. Our aim was to assess the hypothesis that local nitric oxide (NO) generation is also, in part, responsible for tachyphylaxis to ANGII in veins, using the Aellig dorsal hand vein technique. METHODS Eight healthy male volunteers received 600 mg of… CONTINUE READING