Local neurotrophic repression of gene transcripts encoding fetal AChRs at rat neuromuscular synapses

@article{Kues1995LocalNR,
  title={Local neurotrophic repression of gene transcripts encoding fetal AChRs at rat neuromuscular synapses},
  author={Wilfried A Kues and Hans Rudolf Brenner and Bert J. Sakmann and Veit Witzemann},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={130},
  pages={949 - 957}
}
The spatio-temporal expression patterns of mRNA transcripts coding for acetylcholine receptor (AChR) subunits and myogenic factors were measured in denervated rat soleus muscle and in soleus muscle chronically paralyzed for up to 12 d by conduction block of the sciatic nerve by tetrodotoxin (TTX). In denervated muscle the AChR alpha-, beta-, gamma-, and delta-subunit mRNAs were elevated with highest expression levels in the former synaptic and the perisynaptic region and with lower levels in… CONTINUE READING

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