Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction.

@article{Davis2006LocalMI,
  title={Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction.},
  author={Michael H. Davis and Patrick Ching-Ho Hsieh and Tomosaburo Takahashi and Qing Song and Shuguang Zhang and Roger D Kamm and Alan J. Grodzinsky and Piero Anversa and Richard T Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 21},
  pages={8155-60}
}
Strategies for cardiac repair include injection of cells, but these approaches have been hampered by poor cell engraftment, survival, and differentiation. To address these shortcomings for the purpose of improving cardiac function after injury, we designed self-assembling peptide nanofibers for prolonged delivery of insulin-like growth factor 1 (IGF-1), a cardiomyocyte growth and differentiation factor, to the myocardium, using a "biotin sandwich" approach. Biotinylated IGF-1 was complexed with… CONTINUE READING
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