Local modulation of adrenergic neurotransmission in blood vessels.

  title={Local modulation of adrenergic neurotransmission in blood vessels.},
  author={John T. Shepherd and Paul Michel Vanhoutte},
  journal={Journal of cardiovascular pharmacology},
  volume={7 Suppl 3},
Norepinephrine, released from sympathetic nerve terminals, has a key role in adjusting continuously the performance of the cardiovascular system. Although the amount of transmitter released depends primarily on the degree of activation of postganglionic sympathetic fibers, local metabolites and circulating vasoactive substances, in addition to affecting smooth-muscle cells directly, alter the amount of norepinephrine released. Thus, metabolic acidosis, an increase in potassium ions and in… CONTINUE READING


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