Local lymph node assay responses to paraphenylenediamine: intra- and inter-laboratory evaluations.

@article{Warbrick1999LocalLN,
  title={Local lymph node assay responses to paraphenylenediamine: intra- and inter-laboratory evaluations.},
  author={E Vicky Warbrick and Rebecca Jane Dearman and Laura Lea and David A Basketter and I A N Kimber},
  journal={Journal of applied toxicology : JAT},
  year={1999},
  volume={19 4},
  pages={255-60}
}
The murine local lymph node assay (LLNA) is a method for the prospective identification of skin sensitizing chemicals. Proliferative responses induced in lymph nodes draining the site of topical application of the test chemical are measured and those chemicals that induce a stimulation index of three or more compared with concurrent vehicle-treated controls are considered to have the potential to cause skin sensitization. Dose-response data from the LLNA may be used to derive an estimate of… CONTINUE READING
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