Local injection of stem cell factor (SCF) improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells.

@article{Lutz2008LocalIO,
  title={Local injection of stem cell factor (SCF) improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells.},
  author={Matthias Lutz and Mark Rosenberg and Fabian Kiessling and Volker W Eckstein and Thomas Heger and Jutta Krebs and Anthony D. Ho and Hugo A. Katus and Norbert Frey},
  journal={Cardiovascular research},
  year={2008},
  volume={77 1},
  pages={
          143-50
        }
}
AIMS Recent studies have shown that stem cell therapy may alleviate the detrimental effects of myocardial infarction. Yet, most of these reports observed only modest effects on cardiac function, suggesting that there still is need for improvement before widespread clinical use. One potential approach would be to increase migration of stem cells to the heart. We therefore tested whether local administration of stem cell factor (SCF) improves myocardial homing of intravenously infused lin-/c-kit… CONTINUE READING

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